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BIOCOMP'14 Invited Talk - Dr. Mary Yang

Last modified 2014-07-10 06:58

Integrative systems biology approaches to identify disrupted pathways in disease development
Dr. Mary Yang
Director of the Joint Bioinformatics Ph.D. Program of University of Arkansas
Little Rock College of Engineering & Information Technology
University of Arkansas and HHS/FDA/NCTR
Arkansas, USA

Date & Time: 05:20pm - 06:00pm; July 23 (Wednesday), 2014
LOCATION: Platinum Room


    Advancement of next-generation sequencing technologies has facilitated the identification of large number of genomic mutations, including SNPs (single- nucleotide polymorphisms), CNVs (copy number variations) and SV (structure variations). Large-scale genomic, transcriptomic and proteomic data have generated unprecedented opportunities to disease studies in the context of knowing the entire catalog of genetic mutations and related pathways. However genome-wide association studies (GWAS) still remain challenging, many genomic mutations identified by high-throughput approaches either contribute to small disease risk effect, or lesser population due complex molecular interactions and inter-patient heterogeneity. Motivated by our newly developed systems biology approaches, we combine DEG (differential expression of genes) from RNA-seq and PPI (protein-protein interaction) data with the multi-variant eQTL (expression quantitative trait loci) mapping approaches from WGS (whole genome shortgun) data with phenotypic information to identify the disrupted networks relating to the disease development. In addition, incorporating lncRNA (long non-coding RNA) expression data with disease-disrupted networks has offered new insight into the regulatory structure of the disease-associated networks. Our integrative approaches make an important step toward better understanding disease mechanisms and finding better therapeutic drug targets.


    Dr. Mary Yang received the MS, MSECE and Ph.D. degrees from Purdue University, West Lafayette. She joined the National Human Genome Research Institute in 2005, where she has been working on various projects related to genomics and systems biology. She has been Founding Editor-in-Chief of International Journal of Computational Biology and Drug Design, a NIH PubMed fully indexed journal and is on editorial broads of Journal of Supercomputing and International Journal of Pattern Recognition and Artificial Intelligence. She is currently Associate Professor and Director of the Joint Bioinformatics Ph.D. Program of University of Arkansas Little Rock College of Engineering & Information Technology - University of Arkansas for Medical Sciences and Research Affiliate of HHS/FDA/NCTR in Arkansas. She is the recipient of the Bilsland Dissertation Fellowship, the Purdue Research Foundation Fellowship, the ISIBM and IEEE Bioinformatics and Bioengineering Outstanding Achievement Award, and the NIH Fellows Award for Research Excellence.
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